Biology of hormone-sensitive breast cancer in men mapped


Breast cancer in men is rare, and men with breast cancer receive the same anti-hormonal therapy as women. Often with effect, but there was no scientific basis for it before now. Cancer researchers led by Wilbert Zwart from the Netherlands Cancer Institute and Oncode Institute are now the first to clarify how hormones affect tumor DNA in men with breast cancer.
Most tumors in men barely differ biologically from those in women. But in tumors that react badly to anti-hormonal treatment, the researchers saw subtle differences between the two sexes. These new insights constitute another major step towards the best customized treatment for men and women.

The researchers published their findings on February 2 in the scientific journal Nature Communications.

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