An MRI-movie can visualize tumors in the liver prior to
irradiation. This was shown by researcher Tessa van de Lindt at the
Netherlands Cancer Institute. She developed techniques to capture
these moving tumors with MRI. This will save patients an invasive
procedure and gives doctors more certainty on the tumor location.
She will defend her thesis at the University of Amsterdam on the
5th of July.
In the Antoni van Leeuwenhoek hospital, patients with liver
metastases can be treated with radiotherapy. However, accurate dose
delivery is not straightforward, as the liver moves with
respiration and liver tumors are poorly visible on the x-ray images
that are acquired on the radiotherapy system.
On MRI scans, on the other hand, soft tissues such as the liver
are clearly visible. During her PhD research, Tessa van de Lindt
developed techniques to acquire a so-called 4D-MRI, a movie of the
organs. This movie clearly shows the movement of tumors in the
liver. She showed that with this 4D-MRI, liver tumors can be
visualized and tumor motion can be captured accurately prior to
As of last year, patients in the Antoni van Leeuwenhoek can be
treated on the MR-Linac, a new irradiation device integrated with
and MRI scanner. The first patients with liver metastases will be
treated using this technique within the next few months. The 4D-MRI
will eliminate the need for marker implantation close to the liver
tumor, which at the moment is necessary to determine the tumor
position using x-ray images. This is better for the patient and
gives more certainty on the location of the tumor. In the future,
it might help doctors to treat more accurately.
On Friday July 5th Tessa will defend her thesis at
the University of Amsterdam.
Practical information about the defense can be found on the
University of Amsterdam