Role of polycomb-group genes in transcriptional repression, stem cell fate and tumorigenesis

We study transcriptional repression by Polycomb-group (PcG) protein complexes, and the effects of deregulation of PcG genes on development, cell cycle control, cancer and stem cell maintenance. For this a range of conditional polycomb transgenic and knockout mouse models are used in combination with specific cancer-predisposing mutations mimicking closely cognate human cancers. Recent focus is on using CISPR screens in selected polycomb-dependent tumor models to uncover new synthetic lethal interactions and vulnerabilities.

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