Human breast cancer development and progression

My group studies human breast cancer development and progression, as well as therapy response and resistance, in genetically engineered mouse models (GEMMs) and patient-derived tumor xenograft (PDX) models. We have developed mouse models for BRCA1/2-associated breast cancer and invasive lobular carcinoma (ILC), which are used to (1) study tumor cell-intrinsic and -extrinsic mechanisms of breast cancer development and progression; (2) develop novel therapeutic strategies for prevention and treatment of breast tumors; (3) study mechanisms of acquired resistance to targeted therapeutics.

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