Our Technologies

We develop advanced microscopy platforms (e.g. our FLASH, FOCUS, and IMPRINT technologies) that reveal the cellular interplay in intact human tissue resections and model organisms spanning orders of magnitude from single cell level to whole-organ scale. Our approach combines tissue clearing, high-resolution 3D microscopy and 3D-guided molecular profiling, enabling us to map the fate, spatial context, and interactions of cells across entire tissues. By integrating these multidimensional datasets with genetically engineered mouse models and ex vivo assays we dissect the safeguards that normally prevent tumor formation. Tumorigenesis is a multistep process and our technological repertoire enables longitudinal observations from a single mutated cell to an invasive tumor.