Functional genomics for rational tumor and immune cell combination therapy

We use function-based, genome-wide experimental strategies to develop rational combinatorial cancer treatment, targeting both cancer and immune cells. By screening for novel therapeutic targets and predictive biomarkers, we aim to achieve more durable clinical responses for patients. On the one hand, we are increasing our understanding of how cancer cells rewire their signaling networks, to expose and exploit new pharmacologically tractable tumor susceptibilities, also in the context of immunotherapy. On the other hand, we are manipulating various cell types from the patient’s own immune system to boost their specific cytotoxicity towards tumor cells. With these function-based approaches, we develop new rational combinatorial therapies, which simultaneously eliminate the patients’ tumors and harness their immune system.

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