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Our technologies


 

Click on the links for relevant publications, protocols and other resources.

Technologies for chromatin genomics and genome editing we have developed 

  • DamID and pA-DamID: methods for the mapping of in vivo protein-genome interactions.
  • m6A-tracer: a derivative of DamID, to visualize DNA that has contacted a protein of interest in living cells.
  • TRIP: a method to measure the impact of chromatin on gene regulation at thousands of genomic locations in parallel.
  • DSB-TRIP: a variant of TRIP to test the impact of chromatin context on DNA repair.
  • TIDE and TIDER: simple, cheap and quantitative methods to measure genome editing efficiency by CRISPR/Cas9
  • SuRE: a massively parallel reporter assay to map and measure the activity of regulatory elements in entire mammalian genomes.

New tools under development

  • A tool to separate genomic loci (such as enhancers and promoters) spatially inside the cell nucleus
  • A variant of SuRE to test the functionality of thousands of enhancer/promoter pairs
  • A screen to find proteins that control gene regulation inside LADs

Plasmids

Most of our important plasmids can be obtained from Addgene. For other plasmids please contact us.

Data & Code

Our datasets and code are available from various repositories:

4D Nucleome: DamID-seq and pA-DamID-seq maps of nuclear lamina interactions
GEO: A variety of whole-genome datasets (DamID, mRNA-seq, TRIP, ...)
OSF: Various types of data (some unpublished), records of lab notebooks
Github: Code of various published and unpublished projects

Contact us if you are interested!

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