Publications

Pharmacogenetics

Polymorphisms affecting function of the human organic cation transporter hOCT1 (SLC22A1): what are the consequences?

Cancer research

Low systemic exposure of oral docetaxel in mice resulting from extensive first-pass metabolism is boosted by ritonavir.

Molecular biology of the cell

Dynamics of the alpha6beta4 integrin in keratinocytes.

The Journal of biological chemistry

TRAIL receptor and CD95 signal to mitochondria via FADD, caspase-8/10, Bid, and Bax but differentially regulate events downstream from truncated Bid.

25-10-2002

The Journal of biological chemistry

Alkyl-lysophospholipid accumulates in lipid rafts and induces apoptosis via raft-dependent endocytosis and inhibition of phosphatidylcholine synthesis.

18-10-2002

Anti-cancer drugs

Stability and compatibility of the investigational polymer-conjugated platinum anticancer agent AP 5280 in infusion systems and its hemolytic potential.

01-10-2002

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Population pharmacokinetics of the novel anticancer agent E7070 during four phase I studies: model building and validation.

01-10-2002

Oncogene

Proviral activation of the tumor suppressor E2a contributes to T cell lymphomagenesis in EmuMyc transgenic mice.

26-09-2002

Journal of immunology (Baltimore, Md. : 1950)

Differential kinetics of antigen-specific CD4+ and CD8+ T cell responses in the regression of retrovirus-induced sarcomas.

15-09-2002

British journal of cancer

A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin.

09-09-2002

Cancer cell

Stable suppression of tumorigenicity by virus-mediated RNA interference.

Cancer chemotherapy and pharmacology

Extremely high exposures in an obese patient receiving high-dose cyclophosphamide, thiotepa and carboplatin.

European journal of nuclear medicine and molecular imaging

Phase 1 study to identify tumour hypoxia in patients with head and neck cancer using technetium-99m BRU 59-21.

Nature genetics

High-throughput retroviral tagging to identify components of specific signaling pathways in cancer.

Diabetic medicine : a journal of the British Diabetic Association

Longitudinal assessment of the development of diabetic polyneuropathy and associated risk factors.

Annals of oncology : official journal of the European Society for Medical Oncology

Late effects of adjuvant chemotherapy on cognitive function: a follow-up study in breast cancer patients.

Nature genetics

Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice.

Anti-cancer drugs

An excretion balance and pharmacokinetic study of the novel anticancer agent E7070 in cancer patients.

Journal of mass spectrometry : JMS

Quantitative analysis of the novel depsipeptide anticancer drug Kahalalide F in human plasma by high-performance liquid chromatography under basic conditions coupled to electrospray ionization tandem mass spectrometry.

Molecular biology of the cell

Agonist-induced PIP(2) hydrolysis inhibits cortical actin dynamics: regulation at a global but not at a micrometer scale.

Nature

A progression puzzle.

22-08-2002

Cancer research

The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells.

15-08-2002

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Determination of 9-nitrocamptothecin and its metabolite 9-aminocamptothecin in human plasma using high-performance liquid chromatography with ultraviolet and fluorescence detection.

05-08-2002

European journal of cancer (Oxford, England : 1990)

Phase I and pharmacological study of daily oral administration of perifosine (D-21266) in patients with advanced solid tumours.

01-08-2002

The Journal of biological chemistry

The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator.

19-07-2002

The EMBO journal

Loss of p27(Kip1) but not p21(Cip1) decreases survival and synergizes with MYC in murine lymphomagenesis.

15-07-2002

Oncogene

Tumor formation in mice with somatic inactivation of the retinoblastoma gene in interphotoreceptor retinol binding protein-expressing cells.

11-07-2002

Cancer chemotherapy and pharmacology

Urinary and fecal excretion of topotecan in patients with malignant solid tumours.

Cancer chemotherapy and pharmacology

A population analysis of the pharmacokinetics of Cremophor EL using nonlinear mixed-effect modelling.

Nature reviews. Immunology

T-cell-receptor gene therapy.

Analytical and bioanalytical chemistry

Determination of total platinum in plasma and plasma ultrafiltrate, from subjects dosed with the platinum-containing N-(2-hydroxypropyl)methacrylamide copolymer AP5280, by use of graphite-furnace Zeeman atomic-absorption spectrometry.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.

Cancer cell

E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest.

Nature genetics

Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers.

The Journal of experimental medicine

Contributions of the T cell receptor-associated CD3gamma-ITAM to thymocyte selection.

Proceedings of the National Academy of Sciences of the United States of America

Specificity and affinity motifs for Grb2 SH2-ligand interactions.

25-06-2002

Methods in enzymology

Assays for gene silencing in yeast.

21-06-2002

Biochimica et biophysica acta

Polycomb repression: from cellular memory to cellular proliferation and cancer.

21-06-2002

The Journal of biological chemistry

Bcl-2 family member Bfl-1/A1 sequesters truncated bid to inhibit is collaboration with pro-apoptotic Bak or Bax.

21-06-2002

Cell

Dot1p modulates silencing in yeast by methylation of the nucleosome core.

14-06-2002

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R115777 in advanced cancer.

01-06-2002

Novartis Foundation symposium

The 2.7 A structure of AChBP, homologue of the ligand-binding domain of the nicotinic acetylcholine receptor.

25-05-2002

Journal of immunology (Baltimore, Md. : 1950)

The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2.

15-05-2002

Journal of immunology (Baltimore, Md. : 1950)

Optimizing the efficacy of epitope-directed DNA vaccination.

15-05-2002

European journal of drug metabolism and pharmacokinetics

Evaluation of the bioequivalence of tablets and capsules containing the novel anticancer agent R115777 (Zarnestra) in patients with advanced solid tumors.

09-05-2002

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

Assessing health status and quality-of-life instruments: attributes and review criteria.

Cancer cell

Senescence: a companion in chemotherapy?

Trends in immunology

Adoptive transfer of T-cell immunity.

Fertility and sterility

A low number of retrieved oocytes at in vitro fertilization treatment is predictive of early menopause.