Publications

Cancer research

The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models.

15-10-2016

Oncotarget

Identification of breast cancer cell subtypes sensitive to ATG4B inhibition.

11-10-2016

Cancer cell

Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome.

10-10-2016

Cancer cell

SOX2 Is the Determining Oncogenic Switch in Promoting Lung Squamous Cell Carcinoma from Different Cells of Origin.

10-10-2016

Journal of controlled release : official journal of the Controlled Release Society

Inherent formulation issues of kinase inhibitors.

10-10-2016

Nature

X-ray structures define human P2X(3) receptor gating cycle and antagonist action.

06-10-2016

Oncogene

Collagen-rich stroma in aggressive colon tumors induces mesenchymal gene expression and tumor cell invasion.

06-10-2016

American journal of human genetics

Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation.

06-10-2016

Breast cancer research : BCR

Patient survival and tumor characteristics associated with CHEK2:p.I157T - findings from the Breast Cancer Association Consortium.

03-10-2016

Cancer

A randomized phase 2 study exploring the role of bevacizumab and a chemotherapy-free approach in HER2-positive metastatic breast cancer: The HAT study (BOOG 2008-2003), a Dutch Breast Cancer Research Group trial.

01-10-2016

Breast (Edinburgh, Scotland)

Don't forget the dentist: Dental care use and needs of women with breast cancer.

01-10-2016

Urologic oncology

Using the neoadjuvant chemotherapy paradigm to develop precision therapy for muscle-invasive bladder cancer.

01-10-2016

Cancer chemotherapy and pharmacology

Patients homozygous for DPYD c.1129-5923C>G/haplotype B3 have partial DPD deficiency and require a dose reduction when treated with fluoropyrimidines.

01-10-2016

The oncologist

Antidrug Antibody Formation in Oncology: Clinical Relevance and Challenges.

01-10-2016

Gastroenterology

Deletion of Polycomb Repressive Complex 2 From Mouse Intestine Causes Loss of Stem Cells.

01-10-2016

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Toward (Hybrid) Navigation of a Fluorescence Camera in an Open Surgery Setting.

01-10-2016

Minerva urologica e nefrologica = The Italian journal of urology and nephrology

Stapling for prostate pedicle management during robot-assisted radical prostatectomy.

01-10-2016

Acta diabetologica

Impact of cancer diagnosis and treatment on glycaemic control among individuals with colorectal cancer using glucose-lowering drugs.

01-10-2016

Assay and drug development technologies

HC StratoMineR: A Web-Based Tool for the Rapid Analysis of High-Content Datasets.

01-10-2016

European journal of human genetics : EJHG

Unsolicited findings of next-generation sequencing for tumor analysis within a Dutch consortium: clinical daily practice reconsidered.

01-10-2016

Journal of clinical pharmacology

The Use of Dried Blood Spots for Pharmacokinetic Monitoring of Vemurafenib Treatment in Melanoma Patients.

01-10-2016

Molecular endocrinology (Baltimore, Md.)

The Estrogen Receptor α-Cistrome Beyond Breast Cancer.

01-10-2016

Breast cancer research and treatment

Subsequent risk of ipsilateral and contralateral invasive breast cancer after treatment for ductal carcinoma in situ: incidence and the effect of radiotherapy in a population-based cohort of 10,090 women.

01-10-2016

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

Erratum to: QLU-C10D: a health state classification system for a multi-attribute utility measure based on the EORTC QLQ-C30.

01-10-2016

Breast (Edinburgh, Scotland)

Toxicity of dual HER2-blockade with pertuzumab added to anthracycline versus non-anthracycline containing chemotherapy as neoadjuvant treatment in HER2-positive breast cancer: The TRAIN-2 study.

01-10-2016

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Multiple training interventions significantly improve reproducibility of PET/CT-based lung cancer radiotherapy target volume delineation using an IAEA study protocol.

01-10-2016

Journal of cancer survivorship : research and practice

Illness perceptions are associated with mortality among 1552 colorectal cancer survivors: a study from the population-based PROFILES registry.

01-10-2016

Journal of pain and symptom management

Cognitive Impairment in a Subset of Breast Cancer Patients After Systemic Therapy-Results From a Longitudinal Study.

01-10-2016

Investigational new drugs

Pharmacokinetics and excretion of (14)C-omacetaxine in patients with advanced solid tumors.

01-10-2016

The journal of pathology. Clinical research

FGFR1, 2 and 3 protein overexpression and molecular aberrations of FGFR3 in early stage non-small cell lung cancer.

01-10-2016

Oncotarget

Secretome proteomics reveals candidate non-invasive biomarkers of BRCA1 deficiency in breast cancer.

27-09-2016

British journal of cancer

Increased pancreatic cancer risk following radiotherapy for testicular cancer.

27-09-2016

Nature communications

Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration.

26-09-2016

International journal of pharmaceutics

Pharmaceutical development of an oral tablet formulation containing a spray dried amorphous solid dispersion of docetaxel or paclitaxel.

25-09-2016

Clinical cancer research : an official journal of the American Association for Cancer Research

WRN Promoter CpG Island Hypermethylation Does Not Predict More Favorable Outcomes for Patients with Metastatic Colorectal Cancer Treated with Irinotecan-Based Therapy.

15-09-2016

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Liquid chromatography-tandem mass spectrometric assay for the T790M mutant EGFR inhibitor osimertinib (AZD9291) in human plasma.

15-09-2016

International journal of cancer

Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer.

15-09-2016

Oncogene

Targeting the RB-E2F pathway in breast cancer.

15-09-2016

BMC health services research

Quality assessments for cancer centers in the European Union.

07-09-2016

Scientific reports

Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs).

07-09-2016

Nature communications

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.

07-09-2016

BMC cancer

Cost-effectiveness and resource use of implementing MRI-guided NACT in ER-positive/HER2-negative breast cancers in The Netherlands.

05-09-2016

The Journal of biological chemistry

The Structure of the Plakin Domain of Plectin Reveals an Extended Rod-like Shape.

02-09-2016

Methods in molecular biology (Clifton, N.J.)

Pooled shRNA Screening in Mammalian Cells as a Functional Genomic Discovery Platform.

02-09-2016

Methods in molecular biology (Clifton, N.J.)

Purification of Immune Cell Populations from Freshly Isolated Murine Tumors and Organs by Consecutive Magnetic Cell Sorting and Multi-parameter Flow Cytometry-Based Sorting.

02-09-2016

BMC cancer

Piloting a generic cancer consumer quality index in six European countries.

02-09-2016

Nature reviews. Molecular cell biology

Applying CRISPR-Cas9 tools to identify and characterize transcriptional enhancers.

01-09-2016

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Phase III Study of Cabozantinib in Previously Treated Metastatic Castration-Resistant Prostate Cancer: COMET-1.

01-09-2016

Cancer immunology, immunotherapy : CII

Systematic review of the use of granulocyte-macrophage colony-stimulating factor in patients with advanced melanoma.

01-09-2016

Oral oncology

Diffusion-weighted-preparation (D-prep) MRI as a future extension of SPECT/CT based surgical planning for sentinel node procedures in the head and neck area?

01-09-2016