Abstract
METHODS AND MATERIALS
Images were acquired using a coronal 2-dimensional, multislice, single-shot turbo spin-echo (TSE) and turbo field-echo (TFE) sequence, which were repeated 30 times. An image-based self-sorting signal (ImS) was extracted from the data, and rigid registration of the diaphragm per slice position was performed and corrected for amplitude variation in the anteroposterior direction. Data were sorted into 10 bins according to amplitude and phase. ImS was validated in 4 healthy volunteers against a navigator signal. Positional variations within bins, missing data, and smoothness of the liver dome were compared between amplitude and phase binning in 10 volunteers. Tumor contrast and registration were investigated in 3 patients.
CONCLUSIONS
An efficient self-sorted 4-dimensional MRI method was developed and validated using standard sequences and fast reconstruction on a LINAC-integrated MRI scanner providing good tumor visibility for daily image-guided liver stereotactic body radiation therapy.
RESULTS
Each ImS was found to be in excellent agreement with the navigator signal with a correlation coefficient of >0.95 and binning differences of <1 bin. Better liver dome smoothness per bin in case of amplitude binning compared with that in phase binning (2.0-2.6 mm vs 2.4-3.7 mm, respectively) is a tradeoff for more missing data (3.5%-17.5% vs 3.5%-4.7%, respectively). Liver lesions were visible in almost all coronal TSE and TFE images, but the lesion boundary was better defined in the TSE images. Rigid registrations could be performed on the tumor area.
PURPOSE
Novel hybrid MR-LINAC devices provide MRI's superior soft-tissue contrast in the treatment room and thus have the potential to increase accuracy of liver stereotactic body radiation therapy (SBRT). Requirements for daily position verification using 4-dimensional MRI include tumor visibility and short acquisition-reconstruction time (preferably <5 min). The proposed method provides fast acquisition-reconstruction time and the flexibility to vary T1- and T2-weighting, using standard imaging sequences for straightforward implementation on an MR-LINAC.