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Direct-to-treatment MRI-guided prostate radiotherapy using a generic patient-agnostic reference plan.

Georgios Tsekas ,
Lisa Wiersema ,
Sanne Conijn ,
Jega Sundaram ,
Uulke A van der Heide ,
Tomas Janssen

Abstract

MATERIAL AND METHODS

The data of ten prostate cancer patients were used to simulate a (DtT) workflow: During fraction 1, patient-specific contour adaptations were performed and a treatment plan was created, which was used for the rest of the fractions. The DtT treatment plans were evaluated against the clinical RT plans using the clinical delineations.

CONCLUSION

Our DtT workflow resulted in adequate PTV coverage at the cost of small increase to the dose of some organs-at-risk and a high overall efficiency gain.

RESULTS

All DtT plans reached sufficient PTV coverage (V3444cGy > 99%), while resulting in comparable OAR dose distributions to the clinical plans.

BACKGROUND

Background and Purpose: Offline plan preparation is a time-consuming step in MRI-guided radiotherapy (MRIgRT). This work explores the use of a patient-agnostic reference plan and delineations for direct-to-treatment (DtT) MRI-guided prostate RT, without any patient-specific treatment preparations.

More about this publication

Technical innovations & patient support in radiation oncology

Volume 37
Pages 100370
Publication date 01-03-2026

Full text links

Publisher website (DOI) 10.1016/j.tipsro.2025.100370
Europe PubMed Central 41626419
Pubmed 41626419

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