Eye-specific quantitative dynamic contrast-enhanced MRI analysis for patients with intraocular masses.

DCE-MRI of 19 uveal melanoma (UM) patients was acquired using a fat-suppressed 3D spoiled gradient echo sequence with TWIST (time-resolved angiography with stochastic trajectories sequence). The analysis consisted of a two-step registration method to correct for both head and eye motion. A T₁ map was calculated to convert signal intensities to concentrations. Subsequently, the Tofts model was fitted voxel wise to obtain K^trans and v_e.

Using this eye-specific analysis, DCE of intraocular masses is possible which might aid in the diagnosis, prognosis and follow-up of UM.

Registration significantly improved the concentration curve quality (p < 0.001). The T₁ of melanotic lesions was significantly lower than amelanotic lesions (888 ms vs 1350 ms, p = 0.03). The average achieved B₁⁺ in the lesions was 91%. The average K^trans was 0.46 min^-1 (range 0.13-1.0) and the average v_e was 0.22 (range 0.10-0.51).

Dynamic contrast enhanced (DCE)-MRI is currently not generally used for intraocular masses as lesions are small, have an inhomogeneous T₁ and the eye is prone to motion. The aim of this paper is to address these eye-specific challenges, enabling accurate ocular DCE-MRI.