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Death Anxiety During the Last Year of Life in Patients With Advanced Cancer: Longitudinal Results From the eQuiPe Study.

Moyke A J Versluis ,
Froukje E de Vries ,
Yvette M van der Linden ,
Hasan Alradhi ,
Marianne Kool ,
Jarmo C B Hunting ,
Hanneke W M van Laarhoven ,
Arnold Baars ,
Sander M de Hosson ,
Wouter K de Jong ,
Mathijs P Hendriks ,
Marieke H J van den Beuken-van Everdingen ,
Tineke J Smilde ,
Magdolen Youssef-El Soud ,
Marjolein H Tilkema-Tiebosch ,
Dirkje Sommeijer ,
Alexander de Graeff ,
Caroline Mandigers ,
Lia van Zuylen ,
Art Vreugdenhil ,
Annemieke van der Padt-Pruijsten ,
Evelien J M Kuip ,
Lobke van Leeuwen-Snoeks ,
Lonneke V van de Poll-Franse ,
Natasja J H Raijmakers

Abstract

METHODS

Data from the prospective, multicentre, observational eQuiPe study were used. Patients with stage IV solid cancer were included (2017-2020) and completed three-monthly questionnaires until death. Death anxiety was measured using a single item from the Problem and Needs in Palliative Care questionnaire (yes, a little bit, or no). Additionally, 32 patients completed the Death and Dying Distress Scale (DADDS). Longitudinal analyses were performed using mixed-effects regression.

CONCLUSIONS

The prevalence of death anxiety does not change in the last year of life and is associated with several psychosocial factors. These findings underscore the value of open communication and care approaches that strengthen adaptive coping and address the relational aspects of distress.

RESULTS

In total, 629 patients were included (mean age: 66 years, SD = 10). During the last year of life, 12%-15% experienced death anxiety, 30%-34% a little, and 52%-58% none. The prevalence of death anxiety remained stable over time and was significantly associated with female sex (OR 2.48), age (OR 0.93), fatigue (OR 1.10), planning (OR 1.84) and acceptance coping (OR 0.20), and social support (OR 1.39). Concerns about the impact of their death on relatives was the most frequently reported issue (84%) in patients with available DADDS data.

BACKGROUND

Death anxiety in patients with advanced cancer may increase during the last year of life due to increasing symptom burden and growing awareness of prognosis.

AIMS

To examine the trajectory of death anxiety during the last year of life in patients with advanced cancer and its associated factors.

More about this publication

Psycho-oncology

Volume 35
Issue nr. 3
Pages e70429
Publication date 01-03-2026

Full text links

Publisher website (DOI) 10.1002/pon.70429
Europe PubMed Central 41839794
Pubmed 41839794

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