Immunity, age, and luminal breast cancer: understanding the Holy Trinity.

Abstract

In 390 patients with stage I-III hormone-receptor positive/HER2-negative breast tumors higher number of Tumor Infiltrating Lymphocytes (TILs)-subtypes, regardless of whether they were immunostimulatory or immunosuppressive, including T-regulatory cells and CD8- and non-CD8 T-cells, are associated with improved distant disease free survival and overall survival at 8 years follow-up.