Abstract
Adolescents and young adults (AYAs, aged 15-39 years at cancer diagnosis) are recognized as a distinct patient group with specific clinical and psychosocial needs requiring tailored care. This article presents the Network of Expertise (NoE) on AYAs with cancer developed through the Joint Action on Network of Expertise to strengthen AYA research and care across Europe. The NoE adopts a structured, collaborative approach aligning national and European Union-level goals, creating a platform for professionals, patient groups, and stakeholders to advance AYA cancer care, influence policy, and reduce disparities among member states. It also promotes cooperation between pediatric and adult oncology services to improve care throughout the cancer continuum. The article highlights the main challenges ahead and emphasizes that their successful resolution depends on shared commitment to collaboration-ultimately aiming to enhance outcomes and quality of life for AYAs with cancer.