Heart dose associated with overall survival in locally advanced NSCLC patients treated with hypofractionated chemoradiotherapy.

Association of heart dose and overall survival was investigated in a cohort including 469 locally-advanced NSCLC patients receiving daily low-dose hypofractionated chemo-radiotherapy. Significant associations were found over a range of dose parameters. Multivariate analysis showed significant associations of heart_V_2Gy:HR=1.007%^-1 (95% CI:1.002-1.013; p=0.006), age:HR=1.026year^-1 (1.011-1.042; p=0.001) and GTV volume:HR=1.001cc^-1 (1.000-1.002; p=0.006) with overall survival.