2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy.
Jingmei Li,
Linda S Lindström,
Jia N Foo,
Sajjad Rafiq,
Marjanka K Schmidt,
Paul D P Pharoah,
Kyriaki Michailidou,
Joe Dennis,
Manjeet K Bolla,
Qin Wang,
Laura J Van 't Veer,
Sten Cornelissen,
Emiel Rutgers,
Melissa C Southey,
Carmel Apicella,
Gillian S Dite,
John L Hopper,
Peter A Fasching,
Lothar Haeberle,
Arif B Ekici,
Matthias W Beckmann,
Carl Blomqvist,
Taru A Muranen,
Kristiina Aittomäki,
Annika Lindblom,
Sara Margolin,
Arto Mannermaa,
Veli-Matti Kosma,
Jaana M Hartikainen,
Vesa Kataja,
Georgia Chenevix-Trench,
,
Kelly-Anne Phillips,
Sue-Anne McLachlan,
Diether Lambrechts,
Bernard Thienpont,
Ann Smeets,
Hans Wildiers,
Jenny Chang-Claude,
Dieter Flesch-Janys,
Petra Seibold,
Anja Rudolph,
Graham G Giles,
Laura Baglietto,
Gianluca Severi,
Christopher A Haiman,
Brian E Henderson,
Fredrick Schumacher,
Loic Le Marchand,
Vessela Kristensen,
Grethe I Grenaker Alnæs,
Anne-Lise Borresen-Dale,
Silje Nord,
Robert Winqvist,
Katri Pylkäs,
Arja Jukkola-Vuorinen,
Mervi Grip,
Irene L Andrulis,
Julia A Knight,
Gord Glendon,
Sandrine Tchatchou,
Peter Devilee,
Robert Tollenaar,
Caroline Seynaeve,
Maartje Hooning,
Mieke Kriege,
Antoinette Hollestelle,
Ans van den Ouweland,
Yi Li,
Ute Hamann,
Diana Torres,
Hans U Ulmer,
Thomas Rüdiger,
Chen-Yang Shen,
Chia-Ni Hsiung,
Pei-Ei Wu,
Shou-Tung Chen,
Soo Hwang Teo,
Nur Aishah Mohd Taib,
Cheng Har Yip,
Gwo Fuang Ho,
Keitaro Matsuo,
Hidemi Ito,
Hiroji Iwata,
Kazuo Tajima,
Daehee Kang,
Ji-Yeob Choi,
Sue K Park,
Keun-Young Yoo,
Tom Maishman,
William J Tapper,
Alison Dunning,
Mitul Shah,
Robert Luben,
Judith Brown,
Chiea Chuen Khor,
Diana M Eccles,
Heli Nevanlinna,
Douglas Easton,
Keith Humphreys,
Jianjun Liu,
Per Hall,
Kamila Czene
Abstract
Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204_A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10(-9)). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.