A functional approach to questions about life, death, and phosphorylation.


The success of the family of kinases as targets for small-molecule cancer therapeutics is probably best illustrated by the efficacy of the drug Gleevec. In spite of this, the function of many of the kinases in the mammalian genome remains unknown. In a recent paper, MacKeigan and colleagues report a functional genetic screen using RNA interference to identify kinases and phosphatases involved in programmed cell death (MacKeigan et al., 2005). Functional annotation is a prerequisite for selection of new drug targets. Such studies may therefore lay the foundation for the next generation of cancer drugs.

More about this publication

Cancer cell
  • Volume 7
  • Issue nr. 6
  • Pages 503-4
  • Publication date 01-06-2005

This site uses cookies

This website uses cookies to ensure you get the best experience on our website.