Cell cycle regulation by the retinoblastoma family of growth inhibitory proteins.


The retinoblastoma family of growth-inhibitory proteins act by binding and inhibiting several proteins with growth-stimulatory activity, the most prominent of which is the cellular transcription factor E2F. In higher organisms, progression through the cell division cycle is accompanied by the cyclical activation of a number of protein kinases, the cyclin-dependent kinases. Phosphorylation of retinoblastoma family proteins by these cyclin-dependent kinases leads to release of the associated growth-stimulatory proteins which in turn mediate progression through the cell division cycle.

More about this publication

Biochimica et biophysica acta
  • Volume 1287
  • Issue nr. 2-3
  • Pages 103-20
  • Publication date 07-06-1996

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