EMBO J (2013) 32: 2672–2684 ; DOI: 10.1038/emboj.2013.188; published online August 23 2013 Long noncoding RNAs (lncRNAs) are a novel class of regulators that play crucial roles in development and disease. Here we highlight the findings by Huang and colleagues that a regulatory lncRNA (treRNA) acts as a scaffold for a new ribonucleic protein complex that inhibits translation of E-cadherin and promotes cell invasion. This work underscores the potential importance of lncRNAs in cancer metastasis.
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