The primary structure of a feline class I gene: striking similarity to HLA-A.


The sequence of a feline class I pseudogene and its comparison with class I genes from other species is presented. The gene isolated is a pseudogene because of the presence of four stop codons and two frame shift mutations in the first- and second-domain encoding exons, as well as a mutation in a splice acceptor site in the third intron. By sequence comparison with the other class I sequences determined to date, the FLA pseudogene is most closely related to the HLA-A locus products (88% nucleotide identity.

More about this publication

  • Volume 30
  • Issue nr. 5
  • Pages 330-4
  • Publication date 01-01-1989

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