Lamina-associated domains: Tethers and looseners.


Lamina-associated domains (LADs) are large heterochromatic regions that are positioned at the nuclear lamina (NL). A major question is how LAD-NL interactions are mediated and controlled. Here, we review recent progress in the search for molecular tethers and looseners of LADs and we discuss the link between LAD-NL tethering, transcription regulation, and genome replication. We also provide a brief summary of technological advances that may uncover new aspects of LAD biology.

More about this publication

Current opinion in cell biology
  • Volume 74
  • Pages 80-87
  • Publication date 01-02-2022

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