Tracking evolution of BRCA1-associated breast cancer.


Single-cell profiling and computational identification of evolutionary paths to BRCA1-associated tumorigenesis predict that PTEN loss and TP53 mutation precede loss of wild-type BRCA1 in basal-like and luminal tumors, respectively.

More about this publication

Cancer discovery
  • Volume 2
  • Issue nr. 6
  • Pages 486-8
  • Publication date 01-06-2012

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