The case for therapeutic overactivation of oncogenic signaling as a potential cancer treatment strategy.


Most targeted cancer drugs inhibit the oncogenic signals to which cancer cells are addicted. We discuss here a counterintuitive approach to cancer therapy, which consists of deliberate overactivation of the oncogenic signals to overload the stress responses of cancer cells. We discuss why such overactivation of oncogenic signaling, combined with perturbation of the stress response pathways, can be potentially effective in killing cancer cells, aiming to inspire further discussion and consideration.

More about this publication

Cancer cell
  • Volume 42
  • Issue nr. 6
  • Pages 919-922
  • Publication date 10-06-2024

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