Publications

Development (Cambridge, England)

Knockout of the Arp2/3 complex in epidermis causes a psoriasis-like disease hallmarked by hyperactivation of transcription factor Nrf2.

15-12-2017

Oncotarget

The adaptive immune system promotes initiation of prostate carcinogenesis in a human c-Myc transgenic mouse model.

07-11-2017

Nature

Cancer drug addiction is relayed by an ERK2-dependent phenotype switch.

12-10-2017

Proceedings of the National Academy of Sciences of the United States of America

DNA damage tolerance in hematopoietic stem and progenitor cells in mice.

15-08-2017

Gut

RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis.

01-06-2017

Transgenic research

A new transgenic mouse model for conditional overexpression of the Polycomb Group protein EZH2.

01-04-2017

Laboratory animals

Studying skin tumourigenesis and progression in immunocompetent hairless SKH1-hr mice using chronic 7,12-dimethylbenz(a)anthracene topical applications to develop a useful experimental skin cancer model.

01-02-2017

Oncoimmunology

Targeting the MAPK and PI3K pathways in combination with PD1 blockade in melanoma.

27-01-2017

International journal of molecular sciences

Dermal Delivery of Constructs Encoding Cre Recombinase to Induce Skin Tumors in Pten^LoxP/LoxP;Braf^CA/+ Mice.

20-12-2016

Cancer cell

SOX2 Is the Determining Oncogenic Switch in Promoting Lung Squamous Cell Carcinoma from Different Cells of Origin.

10-10-2016

Gastroenterology

Deletion of Polycomb Repressive Complex 2 From Mouse Intestine Causes Loss of Stem Cells.

01-10-2016

Cell reports

Transcription Factor NFIB Is a Driver of Small Cell Lung Cancer Progression in Mice and Marks Metastatic Disease in Patients.

19-07-2016

International journal of cancer

Ritonavir inhibits intratumoral docetaxel metabolism and enhances docetaxel antitumor activity in an immunocompetent mouse breast cancer model.

01-02-2016

Annals of oncology : official journal of the European Society for Medical Oncology

Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model.

01-10-2015

EMBO molecular medicine

Intra- and inter-tumor heterogeneity in a vemurafenib-resistant melanoma patient and derived xenografts.

01-09-2015

Genes & development

Paracrine signaling between tumor subclones of mouse SCLC: a critical role of ETS transcription factor Pea3 in facilitating metastasis.

01-08-2015

Cell host & microbe

Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma.

10-06-2015

Biomedical optics express

In vivo nonlinear spectral imaging as a tool to monitor early spectroscopic and metabolic changes in a murine cutaneous squamous cell carcinoma model.

01-12-2014

Cell reports

Parallel in vivo and in vitro melanoma RNAi dropout screens reveal synthetic lethality between hypoxia and DNA damage response inhibition.

20-11-2014

Gastroenterology

Temozolomide increases the number of mismatch repair-deficient intestinal crypts and accelerates tumorigenesis in a mouse model of Lynch syndrome.

01-11-2014

Science (New York, N.Y.)

T cell memory. Skin-resident memory CD8⁺ T cells trigger a state of tissue-wide pathogen alert.

03-10-2014

Cancer research

RB family tumor suppressor activity may not relate to active silencing of E2F target genes.

15-09-2014

The Journal of experimental medicine

Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells.

25-08-2014

Proceedings of the National Academy of Sciences of the United States of America

Multiple cells-of-origin of mutant K-Ras-induced mouse lung adenocarcinoma.

01-04-2014

EMBO molecular medicine

Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells.

01-02-2014

The Journal of investigative dermatology

Reduced susceptibility to two-stage skin carcinogenesis in mice with epidermis-specific deletion of CD151.

01-01-2014

Breast cancer research and treatment

Radiation- and anthracycline-induced cardiac toxicity and the influence of ErbB2 blocking agents.

01-10-2013

Journal of immunology (Baltimore, Md. : 1950)

Blockade of TGF-β signaling greatly enhances the efficacy of TCR gene therapy of cancer.

15-09-2013

Proceedings of the National Academy of Sciences of the United States of America

Osteoclast precursors in murine bone marrow express CD27 and are impeded in osteoclast development by CD70 on activated immune cells.

23-07-2013

Scientific reports

Defined lipid analogues induce transient channels to facilitate drug-membrane traversal and circumvent cancer therapy resistance.

07-06-2013

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Sensitive method for plasma and tumor Ko143 quantification using reversed-phase high-performance liquid chromatography and fluorescence detection.

15-01-2013

Cancer discovery

Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors.

01-01-2013

Proceedings of the National Academy of Sciences of the United States of America

Loss of integrin α3 prevents skin tumor formation by promoting epidermal turnover and depletion of slow-cycling cells.

26-12-2012

PloS one

EZN-2208 (PEG-SN38) overcomes ABCG2-mediated topotecan resistance in BRCA1-deficient mouse mammary tumors.

03-10-2012

Cancer cell

Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis.

11-09-2012

Cancer prevention research (Philadelphia, Pa.)

Lack of ABCG2 shortens latency of BRCA1-deficient mammary tumors and this is not affected by genistein or resveratrol.

01-08-2012

PloS one

GFAP-Cre-mediated transgenic activation of Bmi1 results in pituitary tumors.

11-05-2012

Cancer research

Impact of intertumoral heterogeneity on predicting chemotherapy response of BRCA1-deficient mammary tumors.

01-05-2012

The Journal of clinical investigation

Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer.

01-05-2012

Nature

Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours.

22-02-2012

Cancer cell

Cell of origin of small cell lung cancer: inactivation of Trp53 and Rb1 in distinct cell types of adult mouse lung.

14-06-2011

The Journal of pathology

Loss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression.

01-05-2011

PloS one

Functional characterization of human cancer-derived TRKB mutations.

17-02-2011

Nature medicine

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy.

01-05-2010

Cancer research

Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan.

15-02-2010

Cancer research

Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity.

01-12-2009

Blood

Mice deficient for CD137 ligand are predisposed to develop germinal center-derived B-cell lymphoma.

10-09-2009

Molecular and cellular biology

A Twist-Snail axis critical for TrkB-induced epithelial-mesenchymal transition-like transformation, anoikis resistance, and metastasis.

01-07-2009

Proceedings of the National Academy of Sciences of the United States of America

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs.

04-11-2008

Journal of immunology (Baltimore, Md. : 1950)

TCR gene therapy of spontaneous prostate carcinoma requires in vivo T cell activation.

15-08-2008