Publications

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

Understanding resistance to targeted cancer drugs through loss of function genetic screens.

01-10-2012

Bioinformatics (Oxford, England)

A regression model for estimating DNA copy number applied to capture sequencing data.

15-09-2012

Journal of cellular and molecular medicine

Identification of F-box only protein 7 as a negative regulator of NF-kappaB signalling.

01-09-2012

Oncogene

Targeting the epigenome for treatment of cancer.

23-08-2012

Breast cancer research and treatment

Deoxycytidine kinase is overexpressed in poor outcome breast cancer and determines responsiveness to nucleoside analogs.

01-02-2012

Nature

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.

26-01-2012

PloS one

The histone demethylase Jarid1b (Kdm5b) is a novel component of the Rb pathway and associates with E2f-target genes in MEFs during senescence.

08-10-2011

Cancer discovery

Functional subtyping of breast cancer.

01-08-2011

Nature medicine

Taming the dragon: genomic biomarkers to individualize the treatment of cancer.

01-03-2011

Nature cell biology

TSPYL5 suppresses p53 levels and function by physical interaction with USP7.

01-01-2011

Cancer research

Twenty-second annual Pezcoller Symposium: RNA biology and cancer.

15-12-2010

Cell

NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.

23-07-2010

Clinical cancer research : an official journal of the American Association for Cancer Research

Inhibition of the PI3K pathway: hope we can believe in?

15-06-2010

Molecular cancer research : MCR

The deubiquitinating enzyme USP26 is a regulator of androgen receptor signaling.

01-06-2010

Cell

It's diagnostics, stupid.

02-04-2010

Molecular cancer research : MCR

Interleukin-1R-associated kinase 2 is a novel modulator of the transforming growth factor beta signaling cascade.

01-04-2010

Carcinogenesis

Functional identification of LRF as an oncogene that bypasses RASV12-induced senescence via upregulation of CYCLIN E.

01-02-2010

Oncogene

Loss-of-function genetic screens as a tool to improve the diagnosis and treatment of cancer.

17-12-2009

Molecular cancer research : MCR

UNC45A confers resistance to histone deacetylase inhibitors and retinoic acid.

01-11-2009

Clinical cancer research : an official journal of the American Association for Cancer Research

Candidate biomarkers of response to an experimental cancer drug identified through a large-scale RNA interference genetic screen.

15-09-2009

Cancer cell

ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome.

07-04-2009

PloS one

A large scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway.

12-03-2009

Biochimica et biophysica acta

Protein phosphatase 2A regulatory subunits and cancer.

01-01-2009

The international journal of biochemistry & cell biology

Molecular basis of the anti-cancer effects of histone deacetylase inhibitors.

01-01-2009

Cell

RNAi Delivers Insights into Liver Cancer.

28-11-2008

The Journal of biological chemistry

Transforming growth factor-beta requires its target plasminogen activator inhibitor-1 for cytostatic activity.

05-09-2008

Molecular cancer research : MCR

Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling.

01-09-2008

British journal of cancer

PRAME expression and clinical outcome of breast cancer.

05-08-2008

PLoS genetics

A RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRC.

01-12-2007

Proceedings of the National Academy of Sciences of the United States of America

A functional genetic screen identifies retinoic acid signaling as a target of histone deacetylase inhibitors.

06-11-2007

Cancer cell

A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.

01-10-2007

Nederlands tijdschrift voor geneeskunde

[The Nobel Prize in Physiology or Medicine for 2006 for the discovery of RNA interference].

30-12-2006

The New England journal of medicine

Exploring the uses of RNAi--gene knockdown and the Nobel Prize.

07-12-2006

Cell

Re-evaluating cell-cycle regulation by E2Fs.

01-12-2006

Cell cycle (Georgetown, Tex.)

Senescence, wound healing and cancer: the PAI-1 connection.

01-12-2006

Cancer research

A causal role for the human tumor antigen preferentially expressed antigen of melanoma in cancer.

15-11-2006

Nature methods

shRNA libraries and their use in cancer genetics.

01-09-2006

The Journal of biological chemistry

A functional genetic screen identifies TFE3 as a gene that confers resistance to the anti-proliferative effects of the retinoblastoma protein and transforming growth factor-beta.

04-08-2006

Nature cell biology

Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence.

01-08-2006

The British journal of dermatology

An evaluation of the efficacy of topical application of salicylic acid for the treatment of familial cylindromatosis.

01-07-2006

Proceedings of the National Academy of Sciences of the United States of America

PR130 is a modulator of the Wnt-signaling cascade that counters repression of the antagonist Naked cuticle.

04-04-2006

Nature chemical biology

An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors.

01-04-2006

Cell

A genomic and functional inventory of deubiquitinating enzymes.

02-12-2005

Methods in enzymology

Functional annotation of deubiquitinating enzymes using RNA interference.

09-11-2005

Nature cell biology

The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene.

01-11-2005

Cell

The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling.

23-09-2005

Cold Spring Harbor symposia on quantitative biology

Functional identification of cancer-relevant genes through large-scale RNA interference screens in mammalian cells.

25-08-2005

Cell

A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity.

17-06-2005

Cancer cell

A functional approach to questions about life, death, and phosphorylation.

01-06-2005

Molecular cell

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.

04-02-2005