Publications

Cancer informatics

The Melanoma MAICare Framework: A Microsimulation Model for the Assessment of Individualized Cancer Care.

28-06-2016

Trials

A phase I followed by a randomized phase II trial of two cycles carboplatin-olaparib followed by olaparib monotherapy versus capecitabine in BRCA1- or BRCA2-mutated HER2-negative advanced breast cancer as first line treatment (REVIVAL): study protocol for a randomized controlled trial.

21-06-2016

Oncotarget

Neoadjuvant tamoxifen synchronizes ERα binding and gene expression profiles related to outcome and proliferation.

07-06-2016

Nederlands tijdschrift voor geneeskunde

[Living with incurable cancer].

29-04-2016

Cell

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility.

07-04-2016

Breast cancer research and treatment

Equivalence of MammaPrint array types in clinical trials and diagnostics.

01-04-2016

Breast cancer research and treatment

Very low local recurrence rates after breast-conserving therapy: analysis of 8485 patients treated over a 28-year period.

01-04-2016

Journal of proteome research

Targeted MS Assay Predicting Tamoxifen Resistance in Estrogen-Receptor-Positive Breast Cancer Tissues and Sera.

01-04-2016

Journal of neuro-oncology

Response of symptomatic brain metastases from HER-2 overexpressing breast cancer with T-DM1.

01-04-2016

Oncotarget

Annexin-A1 and caldesmon are associated with resistance to tamoxifen in estrogen receptor positive recurrent breast cancer.

19-01-2016

Scientific reports

Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer.

05-01-2016

Molecular oncology

4-protein signature predicting tamoxifen treatment outcome in recurrent breast cancer.

01-01-2016

Molecular cancer therapeutics

High XIST and Low 53BP1 Expression Predict Poor Outcome after High-Dose Alkylating Chemotherapy in Patients with a BRCA1-like Breast Cancer.

01-01-2016

Cureus

Ongoing Remission Nineteen Years after High-dose Chemotherapy for Oligometastatic Breast Cancer; What Can We Learn from this Patient?

24-12-2015

Breast (Edinburgh, Scotland)

St. Gallen endocrine response classes predict recurrence rates over time.

01-12-2015

Genes, chromosomes & cancer

Copy number profiling by array comparative genomic hybridization identifies frequently occurring BRCA2-like male breast cancer.

01-12-2015

Therapeutic drug monitoring

Dried Blood Spot Self-Sampling at Home for the Individualization of Tamoxifen Treatment: A Feasibility Study.

01-12-2015

Nature reviews. Clinical oncology

Cognitive effects of endocrine therapy for breast cancer: keep calm and carry on?

01-10-2015

Molecular oncology

BRCA1-like signature in triple negative breast cancer: Molecular and clinical characterization reveals subgroups with therapeutic potential.

01-10-2015

BMC cancer

The value of completion axillary treatment in sentinel node positive breast cancer patients undergoing a mastectomy: a Dutch randomized controlled multicentre trial (BOOG 2013-07).

03-09-2015

BMC cancer

Protein Kinase A-induced tamoxifen resistance is mediated by anchoring protein AKAP13.

14-08-2015

Clinical breast cancer

Tailored Tamoxifen Treatment for Breast Cancer Patients: A Perspective.

01-08-2015

Breast cancer research and treatment

The prognostic value of the neoadjuvant response index in triple-negative breast cancer: validation and comparison with pathological complete response as outcome measure.

01-08-2015

Clinical pharmacokinetics

Effects of Pharmacogenetics on the Pharmacokinetics and Pharmacodynamics of Tamoxifen.

01-08-2015

Molecular oncology

Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms.

01-08-2015

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Challenges in the Use of DNA Repair Deficiency As a Biomarker in Breast Cancer.

10-06-2015

Molecular oncology

Decreased expression of ABAT and STC2 hallmarks ER-positive inflammatory breast cancer and endocrine therapy resistance in advanced disease.

01-06-2015

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Molecular profiling is rather likely to be cost effective.

10-05-2015

Clinical cancer research : an official journal of the American Association for Cancer Research

Breast cancers with a BRCA1-like DNA copy number profile recur less often than expected after high-dose alkylating chemotherapy.

15-02-2015

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

Microsimulation Model For The Assessment Of Personalized Cancer Care: The Mapcca Model Framework.

01-11-2014

European journal of cancer (Oxford, England : 1990)

Efficacy of six month neoadjuvant endocrine therapy in postmenopausal, hormone receptor-positive breast cancer patients--a phase II trial.

01-09-2014

International journal of cancer

PI3K/AKT/mTOR pathway activation in primary and corresponding metastatic breast tumors after adjuvant endocrine therapy.

01-09-2014

PloS one

Lack of genomic heterogeneity at high-resolution aCGH between primary breast cancers and their paired lymph node metastases.

02-08-2014

Breast cancer research and treatment

Use of dried blood spots for the determination of serum concentrations of tamoxifen and endoxifen.

01-07-2014

Breast cancer research and treatment

Optimized outcome prediction in breast cancer by combining the 70-gene signature with clinical risk prediction algorithms.

01-06-2014

Nederlands tijdschrift voor geneeskunde

[Gene expression classifiers in the prognosis of breast cancer].

02-05-2014

European journal of cancer (Oxford, England : 1990)

Risk estimations and treatment decisions in early stage breast cancer: agreement among oncologists and the impact of the 70-gene signature.

01-04-2014

The Journal of molecular diagnostics : JMD

MammaPrint molecular diagnostics on formalin-fixed, paraffin-embedded tissue.

01-03-2014

Breast cancer research and treatment

Tamoxifen dose and serum concentrations of tamoxifen and six of its metabolites in routine clinical outpatient care.

01-02-2014

BMC cancer

Hot flashes are not predictive for serum concentrations of tamoxifen and its metabolites.

28-12-2013

British journal of cancer

Neoadjuvant chemotherapy adaptation and serial MRI response monitoring in ER-positive HER2-negative breast cancer.

10-12-2013

European journal of cancer (Oxford, England : 1990)

Prospective cost-effectiveness analysis of genomic profiling in breast cancer.

01-12-2013

Cancer research

Hallmarks of aromatase inhibitor drug resistance revealed by epigenetic profiling in breast cancer.

15-11-2013

European journal of pharmacology

Tamoxifen resistance: from bench to bedside.

05-10-2013

Breast (Edinburgh, Scotland)

Breast cancer in women at high risk: the role of rapid genetic testing for BRCA1 and -2 mutations and the consequences for treatment strategies.

01-10-2013

International journal of cancer

A prospective evaluation of a breast cancer prognosis signature in the observational RASTER study.

15-08-2013

Breast cancer research and treatment

CYP2C19 2 predicts substantial tamoxifen benefit in postmenopausal breast cancer patients randomized between adjuvant tamoxifen and no systemic treatment.

01-06-2013

Breast cancer research and treatment

Platform comparisons for identification of breast cancers with a BRCA-like copy number profile.

01-06-2013

The breast journal

Paclitaxel, carboplatin, and trastuzumab in a neo-adjuvant regimen for HER2-positive breast cancer.

21-05-2013

Breast (Edinburgh, Scotland)

Additional value of the 70-gene signature and levels of ER and PR for the prediction of outcome in tamoxifen-treated ER-positive breast cancer.

01-12-2012