Publications

Cell reports

Perturbations in 3D genome organization can promote acquired drug resistance.

20-09-2023

Molecular oncology

MND1 enables homologous recombination in somatic cells primarily outside the context of replication.

01-07-2023

Cancer cell

Taxanes trigger cancer cell killing in vivo by inducing non-canonical T cell cytotoxicity.

12-06-2023

Cancer discovery

UNCAN.eu, a European Initiative to UNderstand CANcer.

02-11-2022

DNA repair

From fluorescent foci to sequence: Illuminating DNA double strand break repair by high-throughput sequencing technologies.

01-10-2022

Nucleic acids research

Double-strand break toxicity is chromatin context independent.

23-09-2022

PloS one

Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity.

07-09-2022

Cancer discovery

Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence.

02-09-2022

Chromosoma

Life of double minutes: generation, maintenance, and elimination.

01-09-2022

PloS one

The impact of monosomies, trisomies and segmental aneuploidies on chromosomal stability.

02-07-2022

EMBO reports

Unexpected gene activation following CRISPR-Cas9-mediated genome editing.

03-02-2022

The FEBS journal

A novel assay for screening WIP1 phosphatase substrates in nuclear extracts.

01-10-2021

Cancer research

CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis.

15-08-2021

Nature communications

Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer.

16-07-2021

Science (New York, N.Y.)

3D genomics across the tree of life reveals condensin II as a determinant of architecture type.

28-05-2021

Molecular cell

Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance.

20-05-2021

Cells

Resistance of Hypoxic Cells to Ionizing Radiation Is Mediated in Part via Hypoxia-Induced Quiescence.

10-03-2021

Frontiers in pharmacology

The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity.

09-03-2021

Cells

Combined Inactivation of Pocket Proteins and APC/C^Cdh1 by Cdk4/6 Controls Recovery from DNA Damage in G1 Phase.

04-03-2021

BMC biology

Sustained CHK2 activity, but not ATM activity, is critical to maintain a G1 arrest after DNA damage in untransformed cells.

19-02-2021

The EMBO journal

Centrosomes: Please keep your social distance!

15-02-2021

Cell reports

A FOXO-dependent replication checkpoint restricts proliferation of damaged cells.

26-01-2021

SLAS discovery : advancing life sciences R & D

Combining Supervised and Unsupervised Machine Learning Methods for Phenotypic Functional Genomics Screening.

01-07-2020

Molecular cell

Life in the (Pluripotent) Fast Lane: Cdk1 Preserves the Epigenome to Maintain Pluripotency.

07-05-2020

Proceedings of the National Academy of Sciences of the United States of America

Targeting the cyclin-dependent kinase 5 in metastatic melanoma.

07-04-2020

Nature communications

Degree and site of chromosomal instability define its oncogenic potential.

20-03-2020

EMBO reports

PHF6 promotes non-homologous end joining and G2 checkpoint recovery.

07-01-2020

Nederlands tijdschrift voor geneeskunde

[Environmental regulations impede cancer research and treatment].

05-12-2019

Molecular cell

Distinct Roles for Condensin's Two ATPase Sites in Chromosome Condensation.

05-12-2019

The EMBO journal

Killing a zombie: a full deletion of the BUB1 gene in HAP1 cells.

15-11-2019

Molecular cell

Life or Death after a Break: What Determines the Choice?

17-10-2019

Trends in genetics : TIG

Consequences of Genomic Diversification Induced by Segregation Errors.

01-04-2019

Nature reviews. Cancer

Cytokinesis defects and cancer.

01-01-2019

Molecular & cellular proteomics : MCP

Doxorubicin-induced DNA Damage Causes Extensive Ubiquitination of Ribosomal Proteins Associated with a Decrease in Protein Translation.

01-12-2018

Nucleic acids research

A limited number of double-strand DNA breaks is sufficient to delay cell cycle progression.

02-11-2018

Journal of the American Chemical Society

Photoactivation of MDM2 Inhibitors: Controlling Protein-Protein Interaction with Light.

17-10-2018

Nature communications

Persistent repair intermediates induce senescence.

25-09-2018

Current biology : CB

Loss of Kif18A Results in Spindle Assembly Checkpoint Activation at Microtubule-Attached Kinetochores.

10-09-2018

Nature communications

FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence.

19-07-2018

Journal of cell science

Chromosomes trapped in micronuclei are liable to segregation errors.

09-07-2018

British journal of cancer

Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division.

01-06-2018

Nature communications

SUMO targets the APC/C to regulate transition from metaphase to anaphase.

16-03-2018

Cell reports

BUB1 Is Essential for the Viability of Human Cells in which the Spindle Assembly Checkpoint Is Compromised.

06-02-2018

The Journal of cell biology

TORC1 signaling exerts spatial control over microtubule dynamics by promoting nuclear export of Stu2.

06-11-2017

Oncotarget

TUBB3 overexpression has a negligible effect on the sensitivity to taxol in cultured cell lines.

22-09-2017

The Journal of biological chemistry

Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures.

01-09-2017

Chromosoma

Aurora A, MCAK, and Kif18b promote Eg5-independent spindle formation.

01-08-2017

The EMBO journal

ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration.

14-07-2017

Cell reports

p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural Aneuploidies.

20-06-2017

Oncotarget

Stable aneuploid tumors cells are more sensitive to TTK inhibition than chromosomally unstable cell lines.

13-06-2017