Niels Keijzer

I’ve started my project at the Sixma lab in November 2018. Here, I focus on PCNA, a protein with several important roles in replication and DNA damage repair. The focus of my project is on ubiquitination and deubiquitination of PCNA, which is important after DNA damage by UV and allows for DNA Damage Tolerance to take place.

In order to gain new insights into this process, I will try to solve structures of PCNA ubiquitination and deubiquitination complexes.