The Mouse preclinical intervention facility can take care of the whole trajectory of preclinical trial design and execution, including support in the design/setup of the study, design suitable drug formulations, planning and execution of treatments, follow-up of tumor growth and/or metastasis formation, assessment of therapy response and collection of tissues and reporting of data. We can also set up new techniques that are needed for your animal study.
The MCCA preclinical intervention facility is using advanced mouse models as surrogate for cancer patients to identify and validate targets that can be exploited by anti-cancer therapy. The main objective of the preclinical intervention unit is to find and test novel anti-cancer treatments, using the advanced cancer models, such as transgenic (spontaneous) mouse models, orthotopic transplantation models, or human xenograft models that have been developed/established at the NKI. The treatment and longitudinal follow-up of tumors is facilitated by a fully trained and dedicated team of technicians that perform the surgeries and caliper measurements.
Our team will help researchers design high quality animal experiments. The well trained/dedicated team of animal technicians that treat the animals blindly, increases reproducibility of the preclinical animal experiments. This, together with the correct experimental design and the high health and welfare standards in our animal facility, will decrease the total amount of animals used.