Gains and losses of chromosomes
It has widely been shown that gains and losses of chromosomes have very detrimental consequences in healthy cells and very few chromosomal abnormalities are compatible with human life. However, the vast majority of tumors are aneuploid, which means that their cells harbour a wrong number of chromosome. In order to get some insight understanding such a paradox, the researchers focused on the immediate and long-term consequences of aneuploidy in normal cells.