Precursor of breast cancer, or not?


The progression of DCIS – a pre-cancerous lesion – to invasive breast cancer, which can take 10-20 years to observe in the clinic, can now be studied within one year using new mouse models.

An international team of researchers led by the Netherlands Cancer Institute developed a method to better predict the outgrowth of Ductal Carcinoma In Situ (DCIS), a possible precursor of breast cancer, into invasive breast cancer. Using mice into which cells from women with DCIS were inserted, researchers can better identify which DCIS patients are at risk for breast cancer.

The study was published in the scientific journal Cancer Cell and is part of PRECISION, a major international research project on DCIS funded by Cancer Research UK and the Dutch Cancer Society as part of Cancer Grand Challenges – a global funding initiative co-founded by Cancer Research UK and the National Cancer Institute in the US.

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