EurOPDX and PDXnet consortia publish milestone paper on PDX reliability
The tumour microenvironment of PDX mouse models does not introduce different genomic disruptions in tumour cells than the microenvironment of human tumours. This makes PDX models even more reliable cancer models than was already known.
These results were published in Nature Genetics by members of the EurOPDX Consortium, including the Netherlands Cancer Institute, and the US-based PDXNet Consortium. The study was led by Enzo Medico (University of Torino) and Jeffrey Chuang (Jackson Laboratory, Bar Harbor).
“We are proud to have contributed to this common effort of EurOPDX,' comments Marieke van de Ven, head of NKI's Mouse Cancer Clinic.
A committed NKI team led by Marieke van de Ven and Jos Jonkers, senior group leader of the 'Mouse Models of Breast Cancer' group, joined forces and dedicated a huge amount of resources and expertise to EurOPDX. For this Nature Genetics publication, an extensive amount of the genomic analysis has been executed at the NKI by the Jonkers group.
Xing Yi Woo et al., “Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts”, Nature Genetics 7 January 2021.