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  • Dutch Cancer Society awards 10.6m euro in research grants to the Netherlands Cancer Institute

Dutch Cancer Society awards 10.6m euro in research grants to the Netherlands Cancer Institute

17-12-2019

17 December 2019 - Today, the Dutch Cancer Society awarded 13 grants to researchers at the Netherlands Cancer Institute (see overview below). The grants, worth over 10 million euros, will go towards research into the use of augmented reality in the operating theatre, repairing DNA, and the treatment of patients who want to become pregnant following cervical cancer.

Augmented reality in the operating theatre

Surgeons sometimes have difficulty identifying malignancies in tissue while operating. In order to improve precision when excising tumours, surgeon Theo Ruers will receive over €500,000  to develop an augmented reality system that adds previously recorded images of the tumour to live images on the operation monitor. If the development stage runs smoothly, he will use augmented reality in the final year of his research on colon cancer patients with liver metastases.

DNA breaks occur all the time

More fundamental is the study being conducted by Jacqueline Jacobs into DNA repair. She has been awarded a grant of over €640,000. DNA in the body's cells breaks and is repaired again all the time. When problems arise during repair, a cell can become cancerous. Dr Jacobs explains that "we do not yet have a thorough understanding of the repair process". Her research focuses on expanding this body of knowledge. "This type of fundamental research is vital for getting to the heart of DNA repair, which will give us further insights into how cancer develops. Based on that, we can improve diagnostics and treatment methods."

Getting pregnant after cervical cancer

The Dutch Cancer Society awarded gynaecologist Nienke van Trommel almost €400,000 for a study into the treatment of cervical cancer. By giving patients chemotherapy prior to surgery, the operation can be less invasive and the cervix can be spared to a better degree. Van Trommel hopes that this will enable patients to become pregnant and carry the baby to term. She says: "We hope that this new treatment will give women the same survival chances as with surgery alone, and that their odds of having children will increase."

Blood test for ovarian cancer

Gynaecological oncologist Christianne Lok will be using a grant worth over €700,000 for a research project to develop a blood test to determine whether ovarian tumours are benign or malignant, thereby preventing unnecessary surgeries.

Radiologist Astrid Scholten will be using a grant worth over €800,000 to conduct a comparative patient study into whether partial breast radiation treatment before surgery could lead to better cosmetic results than radiation after surgery.

Complete list of projects funded by the Dutch Cancer Society in this round

Onderzoeksprojecten

Projectleider

 Bedrag

Revealing novel modes of DNA repair control by ubiquitin(-like) reversal

Jacqueline Jacobs

 €       641.557

Targeting epigenetic crosstalk in Diffuse Large B Cell Lymphoma

Heinz Jacobs

 €       680.397

Augmented reality for precision surgery in cancer

Theo Ruers

 €       506.414

Prediction tools for Hodgkin lymphoma patients to weigh benefits and harms of different treatment and survivorship care strategies

Floor van Leeuwen

 €       619.246

INTERACTION of hypofractionated radiotherapy with targeted agents, antibodies and immunotherapy

Monique de Jong

 €       495.196

OVI-DETECT; Liquid biopsies for improving the pre-operative diagnosis of ovarian cancer

Christianne Lok

 €       733.534

A universal binding hub on cohesin to control the genome?

Benjamin Rowland

 €       601.637

Neo-Adjuvant Chemotherapy and Less Extensive Surgery in Cervical Cancer to Preserve Fertility (CONTESSA/NEOCON-F)

Nienke van Trommel

 €       393.398

Pre- versus postoperative accelerated partial breast irradiation in early stage breast cancer patients (PAPBI-2). A randomized phase III trial.

Astrid Scholten

 €       803.430

The potential association between circadian disruption and hormone-related cancer risk; prospective cohort study among 59,947 female nurses

Matti Rookus

 €       588.529

Young Investigator Grant

Development of a translational ex-vivo model of 2D cells and organoids as a predictive tool for soft tissue sarcoma.

Winan van Houdt

 €       510.716

 

Infrastructure

ScreeninC: a national infrastructure for functional genome editing and large scale functional genomic screening

Roderick Beijersbergen

 €    2.275.668

Nationwide infrastructure integrating research and health care to improve management for Dutch women with familial breast cancer risk

Matti Rookus

 €    1.779.418

 

 

Research projects led by other institutes

NKI researcher

Study of breast cancer genes in men with metastatic prostate cancer, aimed at detecting relatives with an increased risk of getting cancer.

Eveline Bleiker

 €       607.471

Evaluating and ameliorating multidisciplinary treatment of rectal cancer within the Netherlands.

Corrie Marijnen

 €       835.045

 

Jacqueline Jacobs group Other tumors

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