“We will manipulate which molecules interact with each other. We can make existing interactions between a kinase and a partner protein tighter, for example, by bringing in a third party. Or we introduce kinases to molecules they don’t normally ‘see’. This could initiate new processes or cause protein degradation, both of which could help kill cancer cells. This new field, called induced proximity, is very exciting!”
“I was looking for an institute where I could bring my scientific vision to life, and work in an environment where science is closely intertwined with the clinic. I’m really looking forward to thinking about my fundamental science in an applied way and tailoring it to patients’ needs. It inspires me that the NKI has a whole load of amazing research groups.”
“We’ll start with one technician and one PhD student. I received many promising applications for my first position, so that’s great. I’m lucky with the facilities at the NKI: they are amazing and nearly everything my group needs is there already, so we can start up quite quickly.”
“Yes, horses! I love to work with an animal. This the main thing I do outside of my research. Ever since I left the UK in 2018, I have had my own horse. He will be joining us in Amsterdam [she smiles].”
“To me, participating in non-profit research is a very inspiring quest. I really like the idea of trying to disentangle the complex, dynamic reality of our cells and having the opportunity to discover new things that can make a difference for society. Even if it is only for a small subset of patients. In the end: every patient matters, right?”