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Webinar by Lee Kraus

New Pathways and Mechanisms of PARPs and ADP-ribosylation in Cancer: From Nucleosomes to Ribosomes

Friday 30 April 2021 16:00 - 17:00 Zoom webinars (NKI employees only) Seminar

Lee Kraus
Green Center for Reproductive Biology Sciences, UT Southwestern Medical Center, Dallas, USA

W. Lee. Kraus, Ph.D. is a molecular endocrinologist who has contributed to our understanding of global transcriptional regulation in response to nuclear signaling by estrogens and NAD+. His studies on nuclear receptors, coregulators, poly(ADP-ribose) polymerases (PARPs), and chromatin have provided new molecular insights and changed our understanding of the crucial connections between cellular metabolism and gene regulation in the endocrine control of reproduction, inflammation, differentiation, and cancer. Dr. Kraus has also developed computational tools to integrate and analyze data from a wide variety of genomic approaches to study the immediate and direct effects of estrogen and nuclear NAD+ signaling on the transcriptome. These studies have revealed the diverse ways in which genomes are organized, transcribed, and regulated.  In addition, they have revealed new facets of enhancer assembly and function, as well as the expression of thousands of previously unannotated noncoding RNA transcripts of unknown function.  Dr. Kraus is a cofounder of Ribon Therapeutics, Inc. and ARase Therapeutics, Inc.

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