Mistakes in DNA happen quite often in cells. During cell division for example. These mistakes can be small mutations, but there are times when larger sections of DNA end up in the wrong place. I studied whether these structural variations, as we call them, are helpful or harmful. These variations are usually repaired in healthy cells, but when that’s no longer an option, the cell dies in a controlled way. This repair system often malfunctions in tumors, which means that these variations can lead to an accumulation of errors.
My research focused mainly on colorectal tumors. Many DNA errors in these tumors increase the risk of recurrence after surgery. I also discovered two genes involved in this process that hadn’t been identified before. Lab experiments confirmed my findings.
I enjoy experiments in my free time as well: with plants and vegetables in my garden. While gardening, I reflect on the challenges in my latest research, which is currently at UMC Utrecht, where I’m working towards new treatments for metabolic diseases in children.
Soufyan Lakbir will defend his thesis on October 29.
Research at the Netherlands Cancer Institute is financially supported by KWF Dutch Cancer Society and the AVL Foundation.
prof. dr. J. Heringa & prof. dr. G.A. Meijer
prof. dr. S. Abeln & dr. R.J.A. Fijneman