Webinar by Alexandros Pertsinidis
Single-molecule imaging of transcription mechanisms in live cells
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, USA
Dr. Pertsinidis obtained a PhD in Physics from Brown University, where he work on Soft Condensed Matter Physics with Xinsheng Sean Ling. He completed postdoctoral research at Stanford University and at the University of California, Berkeley, working with Steven Chu and Robert Tjian, developing sub-nanometer super-resolution optical imaging techniques and in vitro systems to visualize human Pol II transcription at the single-molecule level. Currently, Dr. Pertsinidis leads a group in the Structural Biology Program at Memorial Sloan Kettering Cancer Center. His group at MSKCC has pioneered new high-resolution and high-sensitivity imaging approaches. Their new tools can now for the first time begin to elucidate transcription, chromatin regulation and genome organization, at specific gene loci and with single-molecule resolution, in live cells.