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Seminar by George Kassiotis

Human endogenous retroviruses and the development of cancer

Friday 2 September 2022 11:00 - 12:00 Piet Borst auditorium with livestream in Zoom (NKI employees only) Seminar

George Kassiotis
Retroviral Immunology, The Francis Crick Institute, London, UK

George Kassiotis is a Senior Group Leader and head of the laboratory of Retroviral Immunology at the Francis Crick Institute, London, UK. He is also a Professor of Retrovirology, at the Department of Infectious Disease, Imperial College London, UK. His laboratory's current work concentrates on innate and adaptive immune responses to retroviruses, particularly of the endogenous type. Recent studies suggests that retrovirus endogenisation events continue to shape host immunity and other physiological systems over long evolutionary times and through diverse mechanisms. Some acquire novel function that provides a host fitness advantage, a process known as exaptation. However, this evolutionary adaptability is also exploited by cancer cells in a process termed onco-exaptation; and both will be discussed.

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