NKI Friday seminar by Ling-Ling Chen
Circular RNA Biology
CAS Center for Excellence in Molecular Cell Science, SIBCB, CAS, Shanghai, China
Ling-Ling Chen’s group studies long noncoding RNAs (lncRNAs), a giant class of RNA molecules that are emerging as important regulators in gene expression networks. Her group has pioneered methods for studying non-polyadenylated RNAs and discovered snoRNA-related lncRNAs and circular RNAs. In addition to the characterization of their unusual biogenesis pathways, her group discovered that some sno-lncRNAs are conspicuously absent from patients with Prader-Willi Syndrome and circular RNAs are involved in innate immunity regulation and related to the autoimmune disease systemic lupus erythematosus. Her group now continues efforts to elucidate the biogenesis and function of these regulatory RNAs in different cellular contexts and in relevant human diseases.