NKI Seminar by Charles Roberts

The SWI/SNF (BAF) Complex: Chromatin, Enhancers and Cancer

Friday 28 April 2023 11:00 - 12:00 Piet Borst Auditorium Seminar

Charles Roberts

Cancer Center Director, St. Jude Children’s Research Hospital, Memphis, TN, USA

Hosts: Lise Dauban and Ningqing Liu

Charles Roberts is a leader in the field of cancer epigenetics, and his research has provided new insights into the central role of chromatin remodeling perturbations in cancer, discoveries that have been translated into investigational therapies for both pediatric and adult cancer patients. His research specifically focuses on the SWI/SNF (BAF) chromatin remodeling complex. Perturbation of this complex has broad relevance to cancer as at least nine genes that encode SWI/SNF subunits are collectively mutated in over 20% of all cancers. Roberts’ laboratory studies both the mechanisms by which SWI/SNF normally regulates chromatin structure and cell fate, and the mechanisms by which mutation of the complex drives cancer formation.text about First name Last Name

NKI Seminar by Charles Roberts

The SWI/SNF (BAF) Complex: Chromatin, Enhancers and Cancer

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