DNA replication at the heart of cell fate decisions and cancer development

9.00-9.10     Opening

9.10-9.35     Maria Elena Torres-Padilla (Helmholtz, Munich)
Emergence and regulation of replication timing during mammalian development

9.40-10.05     Philippe Pasero (CNRS, Montpellier)
Cellular responses to replication stress, from stalled forks to inflammation

10.10-10.35     Fred van Leeuwen (NKI, Amsterdam)
Delineating chromatin rewiring during stress by locus-specific chromatin proteome decoding

10.40-10.55     Marco Barazas (LUMC, Leiden)
Mutational signature catalogue (MUSIC) of DNA double-strand break repair

11.00-11.30      Coffee

11.30-11.55     Julien Duxin (UCPH, Copenhagen) Mechanisms of DNA damage bypass

12.00-12.25     Titia Sixma (NKI, Amsterdam)
Ubiquitin chain trimming regulation in replication and repair

12.30-12.40     Sidrit Uruci (LUMC, Leiden)
CFAP20 salvages arrested RNAPII from the path of co-directional replisomes

12.45-12.55     Puck Knipscheer (Hubrecht Institute, Utrecht)
Polymerase Kappa acts in the repair of aldehyde-lnduced DNA Interstrand crosslinks

13.00-14.00 Lunch

14.00-14.25     Bert Klebl (LDC, Dortmund)
Lead Discovery Center — Paving the way for innovative medicines

14.30-14.55     Heinz Jacobs (NKI, Amsterdam)
DNA damage tolerance in physiology and cancer therapy

15.00-15.25      Nitika Taneja (ErasmusMC, Rotterdam)
Stressed replication bubbles organized into 3-D chromatin loops, coated with heterochromatin and anchored with CTCF for fork protection

15.30-15.40     Sarah Moser (NKI, Amsterdam)
NASP modulates histone turnover to drive PARP inhibitor resistance

15.45-15.55     Bärbel Lorenz (Lumicks, Amsterdam)
Accessing the single-molecule level of DNA replication, DNA repair and chromatin organization via a versatile biochemistry platform

16.00-18.30     Posters with tea, soft drinks in Tiffany's

18.30                Buffet with drinks in Tiffany's

9.00-9.25     Sylvie Noordermeer  (LUMC, Leiden)
Novel approaches to understanding BRCA1’s function in DNA double strand break repair

9.30- 9.55 Francesca Mattiroli (Hubrecht Institute, Utrecht)
Mechanism of chromatin assembly during DNA replication

10.00-10.25      Zoi Lygerou (University of Patras, Patras)
DNA replication licensing aberrations drive replication stress and genomic instability

10.30-10.40      Jolanthe Lingeman (LUMC, Leiden)
Koolen-de Vries syndrome: A repliCation-associated disorder?

10.45-11.15 Coffee

11.1S-11.40     Lorenza Penengo (UZH, Zurich)
Role of the interferon pathway in DNA replication and genome integrity

11.45-12.10     Jacqueline Jacobs (NKI, Amsterdam)
Genome stability maintenance at telomeres and stalled replication forks: emerging roles of MAD2L2

12.15-12.40      Emilio Lecona (CBMSO-CSIC,  Madrid)
Exploring the role of VCP/p97 in the control of DNA replication dynamics

12.45-13.45 Lunch

13.45-14.10 Matthias Altmeyer (UZH, Zurich)
Cellular responses to genotoxic stress across the cell cycle

14.15-14.40      María Gómez (CBMSO-CSIC, Madrid)
Coordination between DNA replication and transcription elongation rates: a requirement for cell plasticity?

14.45-15.10      Juan Méndez (CNIO, Madrid)
Alleviating replication stress via re-priming of DNA synthesis

15.15                Tea and departure