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  • NKI scientists unravel function of mysterious tunnel in clinically important enzyme

    Autotaxin is an important enzyme that is involved in numerous cell signaling processes. For a large part, it's structure and function is known. But the enzyme contains a mysterious tunnel with an unknown function. The team of Netherlands Cancer Institute (NKI) researcher Anastassis Perrakis has shown that certain natural steroids can bind inside this tunnel and inhibit the function of the enzyme.

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  • Additional chemotherapy when treating breast cancer not always required

    The MammaPrint is a test which can be used to predict which women with hormone-sensitive early-stage breast cancer need additional chemotherapy and which do not. A large European study has provided the final evidence of the test's reliability.

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