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Student - Budget Impact Analysis of the MaMaLoc in localizing breast cancer during surgery

Your function within the department

Accurate intra-operative localization of breast cancer within the primary treatment of breast conserving surgery (BCS) has become increasingly important in recent years. Since approximately 25% - 35% of breast cancers is non-palpable and requires a localization procedure to guide identification and surgical resection. Current localization technologies are either inaccurate (Wire-Guided Localization (GL) or very complex and costly (radioactive Seed Localization (RSL)). Therefore, a novel technology was developed in the NKI-AVL that answers the clinical need for an accurate and simple system to localize the tumor, the MaMaLoc.
The MaMaLoc
The MaMaLoc is a magnetic marker of the size of a rice grain that is placed in the tumor at the radiology department maximum 30 days before surgery. During breast conserving surgery (BCS) a clinical metal detector is used to accurately localize the marker and therefore the tumor. The main advantage of the MaMaLoc technology compared to RSL (very accurate technique, but highly complex) is the use of magnetism instead of radioactivity. It is hypothesised that this would lead to lower intervention costs. The MaMaLoc is very promising since the use of radioactivity (in case of RSL) induces a complex regulatory process which explains the very slow and limited clinical adoption over the 15 years it has been on the market. In order to show the benefit of the MaMaLoc to both the institute and other hospitals, a budget impact analysis (BIA) will be conducted to fasten and guide further development and implementation.
Research question(s)

  1. What is the budget impact of using the MaMaLoc in intra-operative localizing breast cancer compared to the radioactive seed localization from a hospitals perspective (3 potential hospitals)?
  2. How could the logistical process of the MaMaLoc be optimized in order to be applicable for any indicated breast cancer patient?

A budget impact analysis will be conducted from a hospital perspective in which the costs of the three processes will be calculated with an Activity Based Cost analysis (ABC). Therefore, the processes should be drafted. Besides the intervention costs, the implementation costs should be estimated and in order to estimate the budget impact for different situations, scenarios will be drafted to estimate the budget impact under various scenarios. Since the process of the MaMaLoc in this moment is not ideal an additional part of this assignment is the optimization of this process.

Your profile

This project is for a master thesis and we are looking for an enthusiastic master student (Health Sciences or Business Administration (with interest in healthcare)) who would like to analyse processes (multidisciplinary) and is interested to guide this promising innovative product into clinical practice (translational process). You will work together with the developer (PhD student) and all the different disciplines that are involved in the different processes.
The project will be supervised by Valesca Retel - postdoc early health technology assessment (UT and NKI-AVL), Melanie Lindenberg - PhD candidate early HTA on innovative technologies in oncology (NKI-AVL - UT), Bram Schermers - PhD candidate MaMaLoc (NKI-AVL - UT).

Your career opportunities and terms of employment



Please send your CV to Melanie Lindenberg ( and/or Valesca Retèl (
Acquisition for this vacancy is not appreciated.