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Postdoctoral researcher tumor development as a consequence of defective DNA mismatch repair and perturbed DNA replication

Your function within the department

The postdoc will join the research group of Hein te Riele, which is part of the division of Tumor Biology & Immunology. Research in the Te Riele group is focussed on tumor development as a consequence of defective DNA mismatch repair and perturbed DNA replication.

Lynch syndrome (LS), a form of hereditary colorectal cancer, is caused by inherited defects in DNA mismatch repair (MMR) genes. However, in case of subtle defects such as the substitution of a single codon, LS cannot be diagnosed until the deleterious consequences of the defect have been confirmed. We have recently developed a high-throughput diagnostic test that can be used to classify such “Variants of uncertain clinical significance”. Our present goal is to implement the test in diagnostic clinical practice. To this aim, the Dutch Cancer Society is supporting the formation of a nation-wide consortium in which the nine Dutch clinical genetics centers cooperate together with two preclinical research labs.
Your task is twofold: first, improve the test in order to include analysis of extra-exonic variants; second, collaborate with clinical geneticists, gastroenterologists and clinical laboratory geneticists to make the test operational in the setting of routine clinical diagnosis.

Further reading:
Houlleberghs et al. PNAS 2016;113:4128-33 and PLoS Genet 2017;13:e1006765.

Your profile

We seek an experienced and ambitious molecular/medical biologist at the postdoctoral level with an interest in fundamental research and its application in clinical practice. Besides a strong commitment to cancer research, extensive expertise in tissue culture and basic molecular biology techniques is essential as well as outstanding communicative skills.

Your career opportunities and terms of employment

You will join a dynamic e-search division and collaborate with scientists and clinicians within and outside the NKI-AVL with expertise in different disciplines. You will have the opportunity to follow high-quality courses offered by the NKI postdoc career development program.
Your temporary employment is for a period of 1 year with possibilities for extension. The gross salary per month will range from € 3.490 to €3.917,- according to the standard postdoc scale and depends on your previous experience. The terms of employment will be in accordance with the CAO Ziekenhuizen (Collective Labour Agreement for Hospitals) and can be consulted at http://www.nvz-ziekenhuizen.nl/cao-kenniscentrum/cao/download.

Amsterdam is a very lively city with many cultural amenities. The institute is located within a 20 minute tram or bicycle ride from the city center and within 20 minutes from Schiphol airport by car, bus or bicycle.

Interested?

For further information about the position, please contact prof. dr. Hein te Riele, division of Tumor Biology & Immunology, tel. +31 20 512 2084 or h.t.riele@nki.nl.

Your application letter and resume can be attached to the application form on our website www.nki.nl. Click on the vacancy you wish to apply for: you will find the application button that will lead you to the application form.  After dispatch of the form you will receive a reaction as soon as possible.