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Postdoctoral Fellow

Your function within the department

The Netherlands Cancer Institute (NKI) is an independent research institute located in the lively city of Amsterdam. The Institute covers all major areas of molecular and cellular cancer biology, with special emphasis on mouse tumor models, immunology, functional screens, cancer cell biology and translational research. The Netherlands Cancer Institute and the Antoni van Leeuwenhoek Hospital form an integrated cancer center, combining a research laboratory and a hospital under one roof in a single, independent organization. All hospital departments have an extensive research program, often in close collaboration with the research laboratory. This research is focused on improving cancer treatment through imaging and molecular diagnostics, new medicine, immunotherapy, improved operating techniques, more effective radiotherapy, and combinations of these, epidemiology and psychosocial research.
The Akkari lab is seeking a talented and enthusiastic individual to investigate the interaction between the tumor microenvironment and therapy resistance. This work will follow on from our recently published data in Nature Medicine, Cell and Genes & Development (see Akkari et al. 2013, 2014, 2015).
 
Postdoctoral fellow (full time, 36 hours/week)
 
Postdoctoral position available starting in September 2019 in the group of Leila Akkari, Division of Tumor Biology and Immunology at the NKI. The appointment is for a period of at least 2 years.
 
Leila Akkari´s research group studies the microenvironment-mediated mechanisms of tumor maintenance and therapeutic resistance to conventional therapy in brain and liver malignancies. In particular, we investigate the acquired resistance mechanisms resulting from alterations in the activation and recruitment of myeloid cells and their mediators in response to standard of care treatment. Our research aims to identify the vulnerabilities in the cancer cell/ stromal compartment heterotypic communication in solid tumors that may be targeted therapeutically.
Our research interests involve the use of in vitro and in vivo systems for the study of brain and liver cancer, including sophisticated imaging, as well as transgenic, cell-tracing mouse models and patients sample analyses.
The ultimate goal of our projects is to improve the understanding of the complexity of the tumor microenvironment to harness its potential, using the brain and liver and experimental settings of cancer inflammation. 

Your profile

We are looking for a talented and enthusiastic computational biologist who is interested in a dynamic and ambitious environment at a top research institution. Her/his role will be to unravel the underlying transcriptional evolution of immune cells in brain tumor macrophages. The successful candidate must have, or be expecting, a Ph.D. in cell and molecular biology/immunology with strong computational biology background and have published in peer-reviewed journals. She/he will be able to effectively communicate scientific ideas, foster collaboration and have a demonstrable capability for independent thinking. Computational skills in immunological research areas is required. 
 
Interested applicants should submit an electronic copy of their CV, the names and contact information of three referees, and a cover letter describing past research experience, current research interests and career goals.
 

Your career opportunities and terms of employment

State-of-the-art facilities: The research groups at the NKI are supported by state-of-the-art equipment and facilities, most with dedicated support staff. The Institute has a large mouse facility with special units for transgenesis, intervention studies, pathology and functional imaging, a genomics facility, a functional screening facility for RNAi and small-molecule libraries, excellent facilities for microscopy, flowcytometry, protein expression and purification, and many more.
 
Inspiring international atmosphere: Approximately 550 people work in the research laboratory and many of the clinicians are involved in research. Work discussions, lectures and seminars are in English and a large number of non-Dutch post-docs, students and staff members contribute to the stimulating and international atmosphere of the Institute.
 
Inviting conditions: We offer a stimulating and interactive research environment, free use of all state-of-the-art facilities, a competitive salary (including possibilities for additional tax-reduction, according to the Collective Labour Agreement General Hospitals based on proven qualifications) and housing facilities in the vicinity of the Institute. The gross salary per month will be € 3.215,- to € 3.917,- (salary scale 55), and depends on previous experience. The terms of employment will be in accordance with the CAO Ziekenhuizen (Collective Labor Agreement for Hospitals).

Interested?

Interested applicants should submit an electronic copy of their CV, the names and contact information of three referents, and a cover letter describing past research experience, current research interests and career goals. For further information and addresses visit our home page (www.akkarilab.com) or contact Leila Akkari at l.akkari@nki.nl. Applications can be submitted via the portal (http://www.nki.nl/working-at-the-nki/) or sent directly to Leila Akkari.