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Postdoc DCIS PRECISION project

Your function within the department

The Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital (NKI-AVL) is a Comprehensive Cancer Center. We are an independent organization where patient care and scientific research are closely linked. Research topics within the NKI cover all major areas of cancer research, with special emphasis on five themes: basic research, image-guided treatment, immune therapy, personalized medicine and survivorship.  Within the Wesseling research group we are currently looking for a postdoc.

Background of our research
Breast cancer is a heterogeneous disease ranging from being non-hazardous to life threatening. Accurate pathological and molecular analyses are key to make accurate predictions regarding prognosis and response to treatment. At the Wesseling group, we aim to find, validate, and implement biomarkers to make more precise and personalized predictions regarding prognosis and response to treatment. We have two major research themes. First, we try to find biomarkers for neoadjuvant chemotherapy response. For this goal we have a unique collection of tissue biopsies, as well as extended clinical data available. A variety of molecular techniques is employed. Second, we aim to make a distinction between aggressive and indolent ductal carcinoma in situ (DCIS), a breast cancer precursor lesion. This research theme is carried out by integrating epidemiology, pathology and molecular analysis. The Wesseling research group currently consists of Jelle Wesseling (PI and pathologist), Esther Lips (staff scientist), a computational biology postdoc, 6 (physician)-PhD students, and three research technicians.

This function
For our DCIS research theme we are looking for a talented postdoc to join the PRECISION team. The PRECISION project is a large international research effort, launched by Jelle Wesseling at the NKI together with local and international collaborators. The PRECISION project is funded through a CRUK “Grand Challenge” award of € 17.5 million and will run for 5 years
PRECISION’s aim is to make a distinction between ductal carcinoma in situ (DCIS) prone to progression from DCIS that will remain silent. To better understand DCIS development and progression a deep molecular characterization will be performed. The postdoc will initiate studies with fresh normal and DCIS tissue material, and will perform multiregional analysis with a variety of molecular techniques, i.e. single cell sequencing, mass spectrometry, etcetera. Studies will be performed in close collaboration with the Jonkers and van Rheenen labs, as well as our international research partners.

Your profile

Your profile: a postdoc with excellent technical and organizational skills
We are seeking a highly committed postdoc with expertise in molecular biology and translational research. Experience in oncology is a pre, as well as large scale data analysis. In addition, good communication skills are essential, as we are working in a multidisciplinary team.

Your career opportunities and terms of employment

The gross salary per month will be € 3.215,- to € 3.917,- (salary scale 55), and depends on previous experience. The terms of employment will be in accordance with the CAO Ziekenhuizen (Collective Labor Agreement for Hospitals).


For further information about the position, please contact Jelle Wesseling, Esther Lips or Jacco van Rheenen.