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PhD student/Postdoctoral Fellow

Your function within the department

The Netherlands Cancer Institute (NKI) is an independent research institute located in the lively city of Amsterdam. The Institute covers all major areas of molecular and cellular cancer biology, with special emphasis on mouse tumor models, immunology, functional screens, cancer cell biology and translational research. The Netherlands Cancer Institute and the Antoni van Leeuwenhoek Hospital form an integrated cancer center, combining a research laboratory and a hospital under one roof in a single, independent organization. All hospital departments have an extensive research program, often in close collaboration with the research laboratory. This research is focused on improving cancer treatment through imaging and molecular diagnostics, new medicine, immunotherapy, improved operating techniques, more effective radiotherapy, and combinations of these, epidemiology and psychosocial research.
The Akkari lab is seeking a talented and enthusiastic individual to investigate the interaction between the tumor microenvironment and therapy resistance. This work will follow on from our recently published data in Nature Medicine, Cell and Genes & Development (see Akkari et al. 2013, 2014, 2015).
 

Your profile

The project Leila Akkari´s research group studies the microenvironment-mediated mechanisms of tumor maintenance and therapeutic resistance to conventional therapy in brain and liver malignancies. In particular, we investigate the acquired resistance mechanisms resulting from alterations in the activation and recruitment of myeloid cells and their mediators in response to standard of care treatment. Our research aims to identify the vulnerabilities in the cancer cell/ stromal compartment heterotypic communication in solid tumors that may be targeted therapeutically. Furthermore, we are also interested in understanding how genetic mutations in cancer cells shape the tumor microenvironment to its advantage in hepatocellular carcinoma.
Our research interests involve the use of in vitro and in vivo systems for the study of brain and liver cancer, including sophisticated imaging, as well as sophisticated transgenic and cell-tracing mouse models and patients sample analyses.
The ultimate goal of our projects is to improve the understanding of the complexity of the tumor microenvironment to harness its potential, using the brain and liver and experimental settings of cancer inflammation.

We are accepting applications from talented and enthusiastic candidates who are interested in a dynamic, stimulating and ambitious environment at a top research institution to perform their PhD or post doc.
The successful post-doc candidate must have, or be expecting, a Ph.D. in cell and molecular biology or immunology and have published in at least one peer-reviewed journal. Application to fellowships and individual grants will be expected. The graduate candidate must have an MSc in molecular/cellular biology or immunology. The successful candidate will be able to effectively communicate scientific ideas, foster collaboration and have a demonstrable capability for independent thinking. Computational skills and mouse experience are a plus.

State-of-the-art facilities The research groups at the NKI are supported by state-of-the-art equipment and facilities, most with dedicated support staff. The Institute has a large mouse facility with special units for transgenesis, intervention studies, pathology and functional imaging, a genomics facility, a functional screening facility for RNAi and small-molecule libraries, excellent facilities for microscopy, flowcytometry, protein expression and purification, and many more.

Inspiring international atmosphere Approximately 550 people work in the research laboratory and many of the clinicians are involved in research. Work discussions, lectures and seminars are in English and a large number of non-Dutch post-docs, students and staff members contribute to the stimulating and international atmosphere of the Institute.

Your career opportunities and terms of employment

Inviting conditions We offer a stimulating and interactive research environment, free use of all state-of-the-art facilities, a competitive salary (including possibilities for additional tax-reduction, according to the Collective Labour Agreement General Hospitals based on proven qualifications) and housing facilities in the vicinity of the Institute. The appointment is for a period of at least 2 years in the case of a postdoc (gross salary per month €3.363,- to €3.774,- according to the FWG-function group 55), and a period of 4 years in the case of a PhD (gross salary per month €2.567,- to €3.162,- according to the PhD student scales of the NKI).

How to apply Interested applicants should submit an electronic copy of their CV, the names and contact information of three referents, and a cover letter describing past research experience, current research interests and career goals. For further information and addresses visit our home page (www.nki.nl) or contact Leila Akkari (currently located at the University of Lausanne in Switzerland but moving in December to the NKI), Leila.Akkari@unil.ch. Applications can be submitted via the portal (http://www.nki.nl/working-at-the-nki/). The closing date is 30/9/2016.

Acquisition for this vacancy is not appreciated.

Interested?