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PhD student / Postdoctoral fellow

Your function within the department

The Netherlands Cancer Institute (NKI) is an independent research institute located in the lively city of Amsterdam. The Institute covers all major areas of molecular and cellular cancer biology, with special emphasis on mouse tumor models, functional screens, cancer cell biology and translational research. The Netherlands Cancer Institute and the Antoni van Leeuwenhoek Hospital form an integrated cancer center, combining a research laboratory and a hospital under one roof in a single, independent organization. All hospital departments have an extensive research program, often in close collaboration with the research laboratory. This research is focused on improving cancer treatment through imaging and molecular diagnostics, new medicine, improved operating techniques, more effective radiotherapy, and combinations of these, epidemiology and psychosocial research.
The Faller lab is seeking a talented and enthusiastic individual to investigate how alterations in RNA translation can affect the genesis and progression of cancer. This work will follow on from our recently published data in Nature (see Faller et al. 2015).
 
The project involves the analysis of translation in models of colorectal cancer. We have previously shown that increased translational elongation in required for the proliferation seen upon Wnt-signalling (an essential step in intestinal transformation), and that specific mRNAs are translated faster than others. This project will probe both the role of these specific mRNAs, and the mechanism of this specificity, using sophisticated in vivo models and state-of-the-art genomics technology. Our ultimate goal is to improve our understanding of the role of translation in cancer, and to identify novel strategies that can be exploited therapeutically to improve patient outcomes.

Your profile

We are seeking a motivated Postdoc who has been awarded (or in the final stages of obtaining) a PhD in a field relevant to cancer biology or RNA translation. You will have published (or be about to publish) in a peer-reviewed journal, be able to communicate scientific ideas effectively and have a demonstrable capability for independent thinking. Experience with in vivo models and approaches such as ribosomal profiling are also desirable but not required.
We also seek a highly motivated PhD student with a degree in biological sciences. Experience with in vivo models and approaches such as ribosomal profiling would be advantageous but not required.

State-of-the-art facilities
The research groups at the NKI-AVL are supported by state-of-the-art equipment and facilities, most with dedicated support staff. The Institute has a large mouse facility with special units for transgenesis, intervention studies, pathology and functional imaging, a genomics facility, a functional screening facility for RNAi and small-molecule libraries, excellent facilities for microscopy, flowcytometry, protein expression and purification, and many more.

Inspiring international atmosphere
Approximately 550 people work in the research laboratory and many of the clinicians are involved in research. Work discussions, lectures and seminars are in English and a large number of non-Dutch post-docs, students and staff members contribute to the stimulating and international atmosphere of the Institute.

Your career opportunities and terms of employment

Inviting conditions
We offer a stimulating and interactive research environment, free use of all state-of-the-art facilities, a competitive salary (including possibilities for additional tax-reduction, according to the Collective Labour Agreement General Hospitals based on proven qualifications) and housing facilities in the vicinity of the Institute. In the case of a postdoc, the appointment is for a period of at least 1.5 years, with a gross salary of €3363 to €3774 per month.  In the case of a PhD, the appointment is for a period of 4 years, with a gross salary of €2567 to €3162 per month.

How to apply
For further information and addresses visit our home page (www.nki.nl) or contact William Faller (currently located at the Beatson Institute in Glasgow but moving in October to the NKI), w.faller@beatson.gla.ac.uk. Applications can be submitted via the portal (http://www.nki.nl/working-at-the-nki/) or send directly to William Faller. The closing date is 29/07/16.

Acquisition for this vacancy is not appreciated.

Interested?