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PhD student - Epigenetic Programming of Lymphocytes

Your function within the department

The Heinz Jacobs / Fred van Leeuwen groups are looking for a PhD student to join the research group of Heinz Jacobs. The Jacobs group is part of the division of Tumor Biology & Immunology at the Netherlands Cancer Institute. The main research focus of the group is DNA Damage Tolerance (DDT), Programmed Mutagenesis and Epigenetic Control of Lymphocyte Development. Fred van Leeuwen and Heinz Jacobs recently were awarded a prestigious NWO TOP Grant to unravel the role of DOT1L in programming lymphocyte development and maintaining their identity and function.

Using established genetically engineered mouse models (GEMMs) the PhD student will address in close collaboration with other team members of the Jacobs/van Leeuwen laboratories the role DOT1L dependent H3K79 methylation in coordinating the development, differentiation, and behavior of lymphocytes. The project covers a broad range of technologies. Excellent core facilities with experienced scientific staff members and lively scientific environment warrant strong support.

Your profile

To address the function of DOT1L at the molecular and cellular level, we seek an ambitious molecular/medical biologist with affinity for bioinformatics.

Your career opportunities and terms of employment

You will be employed for a period of 4 years. The gross salary per month is € 2.665,- to € 3.282 according to the standard PhD scales. The terms of employment will be in accordance with the CAO Ziekenhuizen (Collective Labour Agreement for Hospitals).
Furthermore you will join an international research team in a stimulating and interactive research environment. Amsterdam is a very livable city with many cultural amenities. The institute is located within a 20 minute tram or bicycle ride from the center of Amsterdam and within 20 minutes from Schiphol airport by car, bus or bicycle.


For further information and addresses, please contact Heinz Jacobs, Head of The Division Tumor Biology & Immunology, tel. +31 20 512 2065 or Applications can be submitted via the portal ( and should include your CV, a motivation letter and the contact information of your references.